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首页-小分子抑制剂&激动剂-Epigenetics-Bromodomain-ZEN-3694
ZEN-3694

Chemical Structure : ZEN-3694

CAS No.: 1643947-30-1

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ZEN-3694 (ZEN 3694;ZEN3694)

货号: PC-61977Not For Human Use, Lab Use Only.

ZEN-3694 is a novel potent, orally bioavailable BET bromodomain inhibitor, selectively binds to both bromodomains of the BET proteins, inhibiting the interaction of acetylated histone peptide with IC50 values in low nM range.

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5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3280 In stock
50 mg ￥5280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ZEN-3694 is a novel potent, orally bioavailable BET bromodomain inhibitor, selectively binds to both bromodomains of the BET proteins, inhibiting the interaction of acetylated histone peptide with IC50 values in low nM range.
ZEN-3694 inhibits proliferation of MV4-11 AML cells with an IC50 of 0.2 uM, and inhibits MYC mRNA expression with an IC50 of 0.16 uM.
ZEN-3694 inhibits proliferation synergistically with the AR antagonists enzalutamide and ARN-509 in the AR positive VCAP prostate cancer cell line.

物理化学性质&存储条件

分子量 333.40
分子式 C19H19N5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1H-Imidazo[4,5-b]pyridin-2-amine, 6-(3,5-dimethyl-4-isoxazolyl)-N-methyl-1-(phenylmethyl)-

参考文献

1. Aggarwal RR, et al. Clin Cancer Res. 2020 Oct 15;26(20):5338-5347.

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