ZE132 | PD-1/PD-L1 inhibitor | Probechem Biochemicals

Chemical Structure : ZE132

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ZE132 (ZE 132)

货号: PC-72764Not For Human Use, Lab Use Only.

ZE132 is a potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with IC50 of <0.1 nM.

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生物&药学活性

ZE132 is a potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with IC50 of <0.1 nM.
ZE132 effectively inhibits the PD-1/PD-L1 interactions in vitro, and has a potent affinity to PD-L1.
ZE132 shows robust anti-tumour effects in vivo, better than anti-PD-1 antibody.
ZE132 treatment promotes cytotoxic T-cell tumour infiltration and induces IL-2 expression.
ZE132 elicits strong inhibitory effects on the mRNA expression of TGF-β.

物理化学性质&存储条件

分子量	721.266
分子式	C37H41ClN4O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((5-Chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)(3-(dimethylamino)propyl)amino)ethane-1-sulfonic acid

参考文献

1. Chenglong Liu, et al. Br J Pharmacol. 2021 Jul;178(13):2651-2670.

ZE132 (ZE 132)

生物&药学活性

物理化学性质&存储条件

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ZE132 (ZE 132)

生物&药学活性

物理化学性质&存储条件

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