ZCM-I-1

Chemical Structure : ZCM-I-1

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货号: PC-49181Not For Human Use, Lab Use Only.

ZCM-I-1 is a selective small molecule modulator modulator of the production of reactive oxygen species (ROS) from mitochondrial complex I, does not alter mitochondrial membrane potential and bioenergetics, selectively targets mitochondrial complex I via interactions with the IF site.

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生物&药学活性

ZCM-I-1 is a selective small molecule modulator modulator of the production of reactive oxygen species (ROS) from mitochondrial complex I, does not alter mitochondrial membrane potential and bioenergetics, selectively targets mitochondrial complex I via interactions with the IF site.
ZCM-I-1 dose-dependently suppresses mitoROS production as measured by mitoSOX fluorescence, suppresses the production of mitoROS induced by rotenone.
ZCM-I-1 dose dependently reverses mitochondrial depolarization induced by MPP+, a known complex I inhibitor, in both primary mouse cortical neurons and SHSY5Y cells.
ZCM-I-1 has no effects on mitochondrial membrane potential and the level of ATP in MC65 cells, suggesting no effects on the coupling and bioenergetics of mitochondria.
ZCM-I-1 selectively targets mitochondrial complex I via interactions with the IF site.
ZCM-I-1 selectively modulates the respiration of mitochondrial complex I in in isolated mitochondria from the cerebral cortex of C57BL/6 mic, modulates the maximal rate of ADP stimulated respiration of pyruvate as the complex I substrate, but not with succinate as the complex II substrate.
ZCM-I-1 (50 mg/kg, oral gavage, 5 times/week) exhibits selective modulation on the respiration in in vivo using transgenic AD mice since mitochondrial dysfunction.

物理化学性质&存储条件

分子量	380.444
分子式	C22H24N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(4-hydroxyphenyl)-N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-3-oxopentanamide

参考文献

1. Jakob C Green, et al. J Med Chem. 2020 Oct 22;63(20):11819-11830.

ZCM-I-1

生物&药学活性

物理化学性质&存储条件

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ZCM-I-1

生物&药学活性

物理化学性质&存储条件

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