ZCAN262 | GluA2 modualtor | Probechem Biochemicals

Chemical Structure : ZCAN262

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ZCAN262 (ZCAN 262)

货号: PC-21623Not For Human Use, Lab Use Only.

ZCAN262 is a small molecule that prevents AMPA-mediated excitotoxicity (IC50=8.5 nM) by targeting an allosteric binding site of AMPA glutamate receptor 2 (GluA2).

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生物&药学活性

ZCAN262 is a small molecule that prevents AMPA-mediated excitotoxicity (IC50=8.5 nM) by targeting an allosteric binding site of AMPA glutamate receptor 2 (GluA2).
ZCAN262 (2.5-5 mg/kg. p.o.) significantly improves motor function in the EAE and cuprizone-diet models for MS.
ZCAN262 restores myelination, axon integrity, and oligodendrocytes in the cuprizone-diet mouse model for multiple sclerosis (MS).
ZCAN262 can improve MS pathology without disrupting basal synaptic transmission or measures of recognition memory and spatial learning.

物理化学性质&存储条件

分子量	384.39
分子式	C19H18F2N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-(2,4-difluorobenzyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl)-N,N-dimethylpyrimidine-4-carboxamide

参考文献

1. Zhai D, et al. Sci Adv. 2023 Dec 8;9(49):eadj6187.

ZCAN262 (ZCAN 262)

生物&药学活性

物理化学性质&存储条件

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ZCAN262 (ZCAN 262)

生物&药学活性

物理化学性质&存储条件

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