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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HIV-ZBMA-1
ZBMA-1

Chemical Structure : ZBMA-1

CAS No.: 1975145-64-2

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ZBMA-1 (ZBMA1)

货号: PC-36113Not For Human Use, Lab Use Only.

ZBMA-1 is a potent HIV-1 replication inhibitor (IC50=1.01 uM) that efficiently protects APOBEC3G protein by targeting Vif-APOBEC3G complex.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ZBMA-1 is a potent HIV-1 replication inhibitor (IC50=1.01 uM) that efficiently protects APOBEC3G protein by targeting Vif-APOBEC3G complex.
    ZBMA-1 protected APOBEC3G from Vif-mediated degradation in a dose-dependent manner and induced nonfunctional proviruses, blocked Vif binding to Elongin C.
    ZBMA-1 does not affect the interactions between Vif and APOBEC3G or CBF-β.

    物理化学性质&存储条件

    分子量 325.169
    分子式 C15H9BrN4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(1H-benzo[d]imidazol-2-yl)-3-(6-bromopyridin-3-yl)acrylonitrile

    参考文献

    1. Zhang S, et al. Antiviral Res. 2015 Oct;122:20-7.

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