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首页-小分子抑制剂&激动剂-GPCR-GPR119-ZB-16
ZB-16

Chemical Structure : ZB-16

CAS No.: 1882921-88-1

ZB-16 (ZB40-0016)

货号: PC-20428Not For Human Use, Lab Use Only.

ZB-16 (ZB40-0016) is a potent, selective GPR119 agonist, increase intracellular cAMP with EC50 of 7.25 nM, stimulates incretin secretion.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ZB-16 (ZB40-0016) is a potent, selective GPR119 agonist, increase intracellular cAMP with EC50 of 7.25 nM, stimulates incretin secretion.
    ZB-16 has a significant antidiabetic activity connected with the increase in glucose-stimulated insulin secretion.
    ZB-16 (1 mg/kg, oral) demonstrates hypoglycemic activity in rats with streptozotocin–nicotinamide-induced diabetes.

    物理化学性质&存储条件

    分子量 489.95
    分子式 C23H21ClFN3O4S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    6-(4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)methoxy)-3-fluorophenyl)-2H-benzo[d][1,3]oxathiole 3,3-dioxide

    参考文献

    1. Tyurenkov IN, et al. Front Endocrinol (Lausanne). 2017 Jul 7;8:152.

    2. RUS Patent 2576037 C1.

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