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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Syk-ZAP180013
ZAP180013

Chemical Structure : ZAP180013

CAS No.: 873080-25-2

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ZAP180013 (ZAP-180013)

货号: PC-38018Not For Human Use, Lab Use Only.

ZAP 180013 is a small molecule inhibitor of zeta-chain-associated protein kinase 70 (Zap70) with IC50 of 1.8 uM (fluorescence polarization assay).

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10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ZAP 180013 is a small molecule inhibitor of zeta-chain-associated protein kinase 70 (Zap70) with IC50 of 1.8 uM (fluorescence polarization assay).
ZAP 180013 inhibits the interaction of Zap70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs), within the T-cell antigen receptor (TCR) signaling pathway.

物理化学性质&存储条件

分子量 454.32
分子式 C19H17Cl2N3O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-Chloro-N-[(4-chlorophenyl)methyl]-2-(ethylsulfonyl)-N-(2-furanylmethyl)-4-pyrimidinecarboxamide

参考文献

1. Patrick R Visperas, et al. SLAS Discov. 2017 Mar;22(3):324-331.

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