ZAP-70 inhibitor 26

Chemical Structure : ZAP-70 inhibitor 26

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货号: PC-21065Not For Human Use, Lab Use Only.

ZAP-70 inhibitor 26 is a potent, highly selective ZAP-70 kinase inhibitor with IC50 of 88 nM, shows high selectivity over structurally related Syk (IC50>10 uM).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

ZAP-70 inhibitor 26 is a potent, highly selective ZAP-70 kinase inhibitor with IC50 of 88 nM, shows high selectivity over structurally related Syk (IC50>10 uM).
ZAP-70 inhibitor 26 also shows no activity against a panel of kinases, including Lck, PKCβ2, EGFR, Src, ERK-1, JNK 1, and p38α (IC50>10 uM).

物理化学性质&存储条件

分子量	516.56
分子式	C27H28N6O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(OCC)/C=C/C1=CC=C(CNC2=NC(NC3=CC(OC)=CC(OC)=C3)=C(C(N)=O)C4=NC=CN24)C=C1

参考文献

1. Akihito Hirabayashi, et al. Bioorg Med Chem. 2009 Jan 1;17(1):284-94.