Z839878730 | KK-LC-1 inhibitor | Probechem Biochemicals

Chemical Structure : Z839878730

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Z839878730 (KK-LC-1 inhibitor Z8)

货号: PC-20112Not For Human Use, Lab Use Only.

Z839878730 (KK-LC-1 inhibitor Z8) is a small moelcuel compound targeting KK-LC-1, which is significantly highly expressed in triple-negative breast cancer tissues than in normal breast tissues.

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生物&药学活性

Z839878730 (KK-LC-1 inhibitor Z8) is a small moelcuel compound targeting KK-LC-1, which is significantly highly expressed in triple-negative breast cancer tissues than in normal breast tissues.
Z839878730 (KK-LC-1 inhibitor Z8) exhibits good proliferation inhibition ability in triple-negative breast cancer cell lines with EC50 value of 9.7 µM and 13.67 µM for MDA-MB-231 and MDA-MB-468 cells, respectively, displays poor antiproliferation effect against low KK-LC-1 expression cells, such as MCF7, SKBR3, and MDA-MB-231/KD cells.
Z839878730 (KK-LC-1 inhibitor Z8) significantly inhibits the proliferation, scratch healing, invasion, and migration of MDA-MB-468 cells, also significantly increased the apoptosis ratio and arrested the cell cycle in the G0-G1 phase.
Z839878730 (KK-LC-1 inhibitor Z8) has little tumor-killing effect on human normal mammary epithelial cells MCF10A.
Z839878730 (KK-LC-1 inhibitor Z8) can inhibit the malignant biological behaviors of triple-negative breast cancer cells by MAL2/MUC1-C/PI3K/AKT/mTOR pathway.

物理化学性质&存储条件

分子量	392.52
分子式	C22H24N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-5-(((2,3-dihydro-1H-inden-1-yl)(methyl)amino)methyl)-N-(4-methylbenzyl)-1,3,4-thiadiazole-2-carboxamide

参考文献

1. Xudong Zhu, et al. J Transl Med. 2023 Mar 9;21(1):184.

Z839878730 (KK-LC-1 inhibitor Z8)

生物&药学活性

物理化学性质&存储条件

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Z839878730 (KK-LC-1 inhibitor Z8)

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物理化学性质&存储条件

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