Z1149421873 | NAP1L1 inhibitor | Probechem Biochemicals

Chemical Structure : Z1149421873

加入收藏

Z1149421873 (Z11)

货号: PC-26503Not For Human Use, Lab Use Only.

Z1149421873 (Z11) is a small-molecule inhibitor of NAP1L1 with SPR Kd value of 7.86 nM, inhibits its protein expression in vitro and exerts anti-fibrotic effects in PMCFs.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Z1149421873 (Z11) is a small-molecule inhibitor of NAP1L1 with SPR Kd value of 7.86 nM, inhibits its protein expression in vitro and exerts anti-fibrotic effects in PMCFs.
Z11 significantly suppressed TGF-β1-induced NAP1L1 protein levels in a dose-dependent manner in PMCFs.
Z11 attenuates TGF-β1-induced adult mice cardiac fibroblast activation and collagen production in vitro.
Z11 suppresses AKT/mTOR signaling pathway by modulating NAP1L1/YAP1 interaction in PMCFs.
Z11 regulates YAP1 ubiquitination to activate the AKT/mTOR signaling pathway.
Z11 attenuates post-MI-induced cardiac fibrosis progression in mice.

物理化学性质&存储条件

分子量	442.49
分子式	C26H23FN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-fluoro-4-methylphenyl)-N'-(2-(naphthalen-2-yl)acetyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carbohydrazide

参考文献

1. Yu T, et al. Eur J Pharmacol. 2026 Jan 12;1011:178440.

Z1149421873 (Z11)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Z1149421873 (Z11)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.