Z-Ile-Leu-aldehyde |CAS:161710-10-7 Probechem Biochemicals

Chemical Structure : Z-Ile-Leu-aldehyde

CAS No.: 161710-10-7

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Z-Ile-Leu-aldehyde (Z-IL-CHO;GSI-XII;γ-Secretase inhibitor XII)

货号: PC-43045Not For Human Use, Lab Use Only.

Z-Ile-Leu-aldehyde (Z-IL-CHO, GSI-XII, γ-Secretase inhibitor XII) is a potent gamma-secretase and Notch signaling inhibitor.

规格	价格	库存
2 mg	￥2180	In stock
5 mg	￥3280	In stock
10 mg	￥4980	In stock
25 mg	￥7580	In stock
100 mg		Get quote

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生物&药学活性

Z-Ile-Leu-aldehyde (Z-IL-CHO, GSI-XII, γ-Secretase inhibitor XII) is a potent gamma-secretase and Notch signaling inhibitor.
Z-Ile-Leu-aldehyde (Z-IL-CHO, GSI-XII, γ-Secretase inhibitor XII) induces morphologic erythroid differentiation and promotes hemoglobin production, suppresses short-term growth and colony formation in erythroid leukemia cell lines.
Z-Ile-Leu-aldehyde (Z-IL-CHO, GSI-XII, γ-Secretase inhibitor XII) impairs murine osteoclast differentiation of RANKL-stimulated RAW264.7 cells in vitro.
Z-Ile-Leu-aldehyde (Z-IL-CHO, GSI-XII, γ-Secretase inhibitor XII) exhibits potent anti-MM activity and reduces osteolytic lesions in he murine myeloma model.

物理化学性质&存储条件

分子量	362.4632
分子式	C20H30N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 41 mg/mL
Chemical Name/SMILES	Carbamic acid, N-[(1S,2S)-1-[[[(1S)-1-formyl-3-methylbutyl]amino]carbonyl]-2-methylbutyl]-, phenylmethyl ester

参考文献

1. Okuhashi Y, et al. Anticancer Res. 2010 Oct;30(10):4071-4.

2. Nwabo Kamdje AH, et al. Blood. 2011 Jul 14;118(2):380-9.

Z-Ile-Leu-aldehyde (Z-IL-CHO;GSI-XII;γ-Secretase inhibitor XII)

生物&药学活性

物理化学性质&存储条件

参考文献

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Z-Ile-Leu-aldehyde (Z-IL-CHO;GSI-XII;γ-Secretase inhibitor XII)

生物&药学活性

物理化学性质&存储条件

参考文献

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