Z-944 |CAS:1199236-64-0 Probechem Biochemicals

Chemical Structure : Z-944

CAS No.: 1199236-64-0

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Z-944 (Ulixacaltamide, Z944)

货号: PC-62009Not For Human Use, Lab Use Only.

Z-944 (Ulixacaltamide) is a potent, highly selective and oral T-type calcium channel blocker with IC50 of 50-160 nM for human Cav3.1, Cav3.2, and Cav3.3 channels.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥2980	In stock
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100 mg		Get quote

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生物&药学活性

Z-944 (Ulixacaltamide) is a potent, highly selective and oral T-type calcium channel blocker with IC50 of 50-160 nM for human Cav3.1, Cav3.2, and Cav3.3 channels.
Z-944 (Ulixacaltamide) displays 70 times more potent for T-type blockade than for blockade of the N-type channel (IC50=11 uM).
Z-944 (Ulixacaltamide) potently suppress seizure activity and attenuates burst firing of thalamic reticular nucleus neurons in the GAERS model of absence epilepsy.
Z-944 (Ulixacaltamide) restores cortical synchrony and thalamocortical connectivity in a rat model of neuropathic pain.

物理化学性质&存储条件

分子量	383.89
分子式	C19H27ClFN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[[1-[2-(tert-butylamino)-2-oxoethyl]piperidin-4-yl]methyl]-3-chloro-5-fluorobenzamide

参考文献

1. Tringham E, et al. Sci Transl Med. 2012 Feb 15;4(121):121ra19.

2. Casillas-Espinosa PM, et al. PLoS One. 2015 Aug 14;10(8):e0130012.

3. LeBlanc BW, et al. Pain. 2016 Jan;157(1):255-63.

Z-944 (Ulixacaltamide, Z944)

生物&药学活性

物理化学性质&存储条件

参考文献

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Z-944 (Ulixacaltamide, Z944)

生物&药学活性

物理化学性质&存储条件

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