Z-590 |CAS:433954-52-0 Probechem Biochemicals

Chemical Structure : Z-590

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Z-590 (Z590)

货号: PC-35242Not For Human Use, Lab Use Only.

Z-590 is a potent inhibitor of macrophage migration inhibitory factor (MIF) tautomerase activity.

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生物&药学活性

Z-590 is a potent inhibitor of macrophage migration inhibitory factor (MIF) tautomerase activity.
Z-590 significantly decreases the production of nitric oxide (NO), TNF-α, interleukin (IL)-6, IL-1β, cyclooxygenase (COX-2), inducible nitric oxide synthase (iNOS) as well as reactive oxygen species (ROS) involved in inhibiting MAKPs signalling pathway in LPS-stimulated microglia cells.
Z-590 suppresses cartilage destruction in adjuvant-induced arthritis via inhibition of macrophage inflammatory activatio in vivo.

物理化学性质&存储条件

分子量	376.43
分子式	C21H16N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[(biphenyl-4-ylcarbonyl)carbamothioyl]amino benzoic acid

参考文献

1. Zhang Z, et al. Immunopharmacol Immunotoxicol. 2018 Apr;40(2):149-157.

2. Zhang Y, et al. Clin Exp Pharmacol Physiol. 2016 Nov;43(11):1134-1144.

Z-590 (Z590)

生物&药学活性

物理化学性质&存储条件

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Z-590 (Z590)

生物&药学活性

物理化学性质&存储条件

参考文献

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