Z-5891 | COPS3 inhibitor | Probechem Biochemicals

Chemical Structure : Z-5891

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Z-5891 (Z5891)

货号: PC-26378Not For Human Use, Lab Use Only.

Z-5891 is a highly selective COPS3 inhibitor, exhibits concentration-dependent proliferation-inhibitory activity against 143B cells with IC50 of 3.28 uM.

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生物&药学活性

Z-5891 is a highly selective COPS3 inhibitor, exhibits concentration-dependent proliferation-inhibitory activity against 143B cells with IC50 of 3.28 uM.
Z-5891 treatment significantly inhibited cell migration and invasion capabilities in osteosarcoma cell lines 143B cells and KHOS cells.
Z-5891 synergizes with doxorubicin to suppress osteosarcoma tumor growth and cancer stemness in a mouse xenograft model.
Z-5891 monotherapy significantly reduced expression of classic CSC markers including CD133, NANOG, and SOX2 in subcutaneous osteosarcoma mouse xenograft model.

物理化学性质&存储条件

分子量	380.43
分子式	C20H21FN6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-(1-(3-fluoropyridin-2-yl)pyrrolidin-3-yl)-3-(2-methyl-4-(1H-pyrazol-1-yl)phenyl)urea

参考文献

1. Guo L, et al. Adv Sci (Weinh). 2026 Mar 13:e20913.

Z-5891 (Z5891)

生物&药学活性

物理化学性质&存储条件

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Z-5891 (Z5891)

生物&药学活性

物理化学性质&存储条件

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