Nastorazepide (Z-360) | CCK2 inhibitor | Probechem Biochemicals

Chemical Structure : Z-360

CAS No.: 209219-38-5

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Z-360 (Nastorazepide, Z360)

货号: PC-45389Not For Human Use, Lab Use Only.

Z-360 (Nastorazepide) is a novel potent, orally active CCK-2/gastrin receptor antagonist with Ki of 0.47 nM.

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5 mg	￥1680	In stock
10 mg	￥2680	In stock
25 mg	￥4580	In stock
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100 mg		Get quote

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生物&药学活性

Z-360 (Nastorazepide) is a novel potent, orally active CCK-2/gastrin receptor antagonist with Ki of 0.47 nM.
Z-360 significantly reduces gastrin-induced PKB/Akt phosphorylation in human CCK-2 receptor-expressing cells.
Z-360 significantly inhibits the growth of MiaPaCa2, also suppresses pancreatic tumor growth and prolong survival in a pancreatic carcinoma xenograft model combined with gemcitabine.
Z-360 prevents up-regulation of ephrin B1 gene expression and phosphorylation of NR2B via suppression of interleukin-1 β production in a cancer-induced pain model in mice.

物理化学性质&存储条件

分子量	520.6199
分子式	C29H36N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 32 mg/mL
Chemical Name/SMILES	Benzoic acid, 3-[[[[(3R)-5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-2,3,4,5-tetrahydro-2-oxo-1H-1,5-benzodiazepin-3-yl]amino]carbonyl]amino]-

参考文献

1. Kawasaki D, et al. Cancer Chemother Pharmacol. 2008 Apr;61(5):883-92.

2. Meyer T, et al. Eur J Cancer. 2010 Feb;46(3):526-33.

3. Orikawa Y, et al. Mol Pain. 2010 Oct 28;6:72.

Z-360 (Nastorazepide, Z360)

生物&药学活性

物理化学性质&存储条件

参考文献

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Z-360 (Nastorazepide, Z360)

生物&药学活性

物理化学性质&存储条件

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