Yaddle1

Chemical Structure : Yaddle1

CAS No.: 3041134-13-5

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货号: PC-25587Not For Human Use, Lab Use Only.

Yaddle1 is a potent, specific new-generation Piezo1 agonist with half-maximal effective concentration (MEC50) of 0.4 uM.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

Yaddle1 is a potent, specific new-generation Piezo1 agonist with half-maximal effective concentration (MEC50) of 0.4 uM.
Yaddle1 exhibits a kinetic solubility of 26.72 ± 1.8 μM at pH 7.4, which is 10-fold better than that of Yoda1 (1.22 ± 0.11 μM at pH 7.4).
Yaddle1 trigger a Ca2+ influx response in isolated primary human CD4+ T lymphocytes.

物理化学性质&存储条件

分子量	372.75
分子式	C14H8ClF3N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-{[2-Chloro-6-(trifluoromethyl)benzyl]thio}-5-(pyrazin-2-yl)-1,3,4-oxadiazole

参考文献

1. Goon S, et al. J Med Chem. 2024 May 23;67(10):8225-8246.

Yaddle1

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Yaddle1

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