YZL-51N | SIRT7 inhibitor | Probechem Biochemicals

Chemical Structure : YZL-51N

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YZL-51N (SIRT7 inhibitor)

货号: PC-22579Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

YZL-51N is a potent, selective, NAD+ competitive SIRT7 inhibitor with IC50 of 12.7 uM in Fluor de Lys (FDL) assays, inhibits SIRT7-mediated H3K18ac deacetylation with EC50 of 13.5 uM in dot blot assays.
YZL-51N selectively inhibits SIRT7 deacetylase activity, does not inhibit the deacetylase activities of other sirtuins.
YZL-51N shows potent interactionfor SIRT7 with KD of 3.3 uM in bio-layer interferometry (BLI) assays.
YZL-51N specifically suppresses SIRT7 enzymatic activities in colorectal cancer cells, increases the level of H3K18ac in HCT116 cells.
YZL-51N attenuates DNA damage repair, shows potential for anti-tumor on colorectal cancers.

物理化学性质&存储条件

分子量	330.29
分子式	C17H14O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (Z)-2,4-bis(3,4-dihydroxyphenyl)-4-oxobut-2-enoate

参考文献

1. Tian-Shu Kang, et al. iScience. 2024 May 16;27(6):110014.