YZ129 |CAS:1643120-60-8 Probechem Biochemicals

Chemical Structure : YZ129

CAS No.: 1643120-60-8

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YZ129 (YZ-129;YZ 129)

货号: PC-35998Not For Human Use, Lab Use Only.

YZ129 (YZ-129) is a small molecule inhibitor of HSP90-Calcineurin-NFAT pathway, suppresses TG-induced NFAT nuclear translocation in HeLa cellswith IC50 of 820 nM.

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25 mg	￥1480	In stock
50 mg	￥2380	In stock
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生物&药学活性

YZ129 (YZ-129) is a small molecule inhibitor of HSP90-Calcineurin-NFAT pathway, suppresses TG-induced NFAT nuclear translocation in HeLa cellswith IC50 of 820 nM.
YZ129 also suppressed the expression of NFAT-regulated genes, such as COX2, MMP7, and MMP9, in U87 GBM cells.
YZ129 directly binds to HSP90 to antagonize its chaperoning effect on calcineurin, a Ca2+-sensitive phosphatase that is required for NFAT nuclear translocation and subsequent gene expression.
YZ129 could not only suppress cancer cell growth but also reduce cancer cell movement and migration of of GBM cells in vitro.
YZ129 suppresses the growth of GBM xenografts in vivo.

物理化学性质&存储条件

分子量	300.317
分子式	C19H12N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(isoquinolin-6-ylamino)naphthalene-1,2-dione

参考文献

1. Liu Z, et al. Cell Chem Biol. 2018 Nov 30. pii: S2451-9456(18)30431-8.

YZ129 (YZ-129;YZ 129)

生物&药学活性

物理化学性质&存储条件

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YZ129 (YZ-129;YZ 129)

生物&药学活性

物理化学性质&存储条件

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