YY2201

Chemical Structure : YY2201

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货号: PC-24257Not For Human Use, Lab Use Only.

YY2201 is a highly potent and selective ATR inhibitor with IC50 of 8 nM, >200-fold selective over mTOR.

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生物&药学活性

YY2201 is a highly potent and selective ATR inhibitor with IC50 of 8 nM, >200-fold selective over mTOR.
YY2201 efficiently inhibits tumor progression in broad-spectrum cancer types, YY2201 could dose-dependently induce G2 arrest of the cell cycle in Lovo cells, inhibits DDR and induces cell cycle arrest and apoptosis in cancer cells.
YY2201 shows superior in vivo anticancer efficacy and a better therapeutic index compared to AZD6738 in a lung cancer xenograft model.
YY2201 also exhibits potent cancer suppression effects in combination with chemotherapy in vivo.

物理化学性质&存储条件

分子量	467.54
分子式	C25H25N9O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(7-(3,5-Dimethyl-1-(pyridin-3-yl)-1H-pyrazol-4-yl)-3-(1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-oxa-3-azabicyclo[3.2.1]octane

参考文献

1. Wu M, et al. J Med Chem. 2025 Mar 13;68(5):5292-5311.

YY2201

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物理化学性质&存储条件

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YY2201

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物理化学性质&存储条件

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