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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Arginine Deiminase (PAD)-YW4-03
YW4-03

Chemical Structure : YW4-03

CAS No.: 1374311-13-3

YW4-03

货号: PC-23134Not For Human Use, Lab Use Only.

YW4-03 is a small molecule peptidylarginine deiminase (PAD) inhibitor with IC50 of 5 uM against PAD4, exhibits cell-killing efficacy in osteosarcoma U2OS cells with IC50 of 2.5-5 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

YW4-03 is a small molecule peptidylarginine deiminase (PAD) inhibitor with IC50 of 5 uM against PAD4, exhibits cell-killing efficacy in osteosarcoma U2OS cells with IC50 of 2.5-5 uM.

物理化学性质&存储条件

分子量 477.01
分子式 C27H29ClN4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-N-(1-(benzylamino)-5-(2-chloroacetimidamido)-1-oxopentan-2-yl)-[1,1'-biphenyl]-3-carboxamide

参考文献

1. Yuji Wang, et al. J Biol Chem. 2012 Jul 27;287(31):25941-53.

2. Lai Shi, et al. Mol Cancer Res. 2020 May;18(5):735-747.

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