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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Arginine Deiminase (PAD)-YW3-56
YW3-56

Chemical Structure : YW3-56

CAS No.: 1374311-17-7

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YW3-56 (PAD2/4 inhibitor)

货号: PC-35354Not For Human Use, Lab Use Only.

YW3-56 is a potent peptidylarginine deiminase (PAD) inhibitor with inhibitory activity against PAD2 (IC50=0.5-1 uM) and PAD4 (IC50=1-2 uM), inhibits U2OS cancer cell growth with IC50 of 2.5 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    YW3-56 is a potent peptidylarginine deiminase (PAD) inhibitor with inhibitory activity against PAD2 (IC50=0.5-1 uM) and PAD4 (IC50=1-2 uM), inhibits U2OS cancer cell growth with IC50 of 2.5 uM.
    YW3-56 activates a cohort of p53 target genes, including SESN2, which in turn inhibits the mTORC1 signaling pathway, thereby perturbing autophagy and inhibiting cancerous cell growth, effectively inhibits the growth of triple-negative breast cancer xenograft tumors in nude mice。
    YW3-56 also significantly blocks LPS-induced pulmonary vascular leakage, alleviates acute lung injury, and improves survival in mouse model of lethal LPS-induced endotoxemia.

    物理化学性质&存储条件

    分子量 494.036
    分子式 C27H32ClN5O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-N-(1-(benzylamino)-5-(2-chloroacetimidamido)-1-oxopentan-2-yl)-6-(dimethylamino)-2-naphthamide

    参考文献

    1. Wang Y, et al. J Biol Chem. 2012 Jul 27;287(31):25941-53.

    2. Wang S, et al. Mol Cancer Ther. 2015 Apr;14(4):877-88.

    3. He W, et al. J Surg Res. 2016 Feb;200(2):610-8.

    4. Liang Y, et al. Eur J Pharmacol. 2018 Jul 4. pii: S0014-2999(18)30372-8.

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