YW2065 | Wnt inhibitor, AMPK activator | Probechem Biochemicals

Chemical Structure : YW2065

CAS No.: 2131223-85-1

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YW2065 (YW-2065)

货号: PC-49509Not For Human Use, Lab Use Only.

YW2065 is is a small molecule inhibitor of Wnt signaling by stabilizing Axin-1, also activates the tumor suppressor AMPK, demonstratesexcellent anti-CRC effects in vitro and in vivo.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

YW2065 is is a potent, selective inhibitor of Wnt signaling by stabilizing Axin-1 with IC50 of 2.3 nM in Wnt-HEK293 luciferase gene reporter assays, also activates the tumor suppressor AMPK.

YW2065 demonstrated good potencies in killing human CRC SW480 cells with IC50 of 2.4 uM.

YW2065 activated AMPK through phosphorylation, which in turn led to the phosphorylation of the downstream substrate acetyl-CoA carboxylase (ACC) in a dose-dependent manner.

YW2065 inhibited CRC cell proliferation and growth in vitro.

YW2065 (10 or 50 mg/kg, i.p.) suppressed SW620 tumor growth in vivo.

物理化学性质&存储条件

分子量	407.27
分子式	C20H15BrN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-bromophenyl)-5-methyl-N-(quinolin-2-yl)-1H-pyrazole-4-carboxamide

参考文献

1. Wei Yang, et al. J Med Chem. 2019 Dec 26;62(24):11151-11164.

YW2065 (YW-2065)

生物&药学活性

物理化学性质&存储条件

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YW2065 (YW-2065)

生物&药学活性

物理化学性质&存储条件

参考文献

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