YUM70 | GRP78 inhibitor | Probechem Biochemicals

Chemical Structure : YUM70

CAS No.: 423145-35-1

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YUM70 (YUM-70)

货号: PC-72448Not For Human Use, Lab Use Only.

YUM70 (YUM-70) is a derivative of 8-hydroxyquinoline targeting GRP78, and cytotoxic to pancreatic cancer cell lines (MIA PaCa-2 cell IC50=2.5 uM).

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10 mg	￥2180	In stock
25 mg	￥3580	In stock
50 mg	￥5480	In stock
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生物&药学活性

YUM70 (YUM-70) is a derivative of 8-hydroxyquinoline targeting GRP78, and cytotoxic to pancreatic cancer cell lines (MIA PaCa-2 cell IC50=2.5 uM).
YUM70 dose-dependently decreased PANC-1 and UM59 cell proliferation in 3D-culture systems (IC50<10 uM).
YUM70 upregulates UPR target proteins and induces ER stress and apoptosis via phosphorylation of eIF2α.
YUM70 binds to full-length GRP78 and causes a positive shift in the melting temperature (Tm) of GRP78 in a dose-dependent manner.
YUM70 inhibits GRP78 ATPase activity of the full-length protein with IC50 of 1.5 uM.
YUM70 can up-regulate GRP78 transcription and protein levels.
YUM70 reduces tumor growth in a MIA PaCa-2 xenograft model.

物理化学性质&存储条件

分子量	398.843
分子式	C21H19ClN2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(benzo[d][1,3]dioxol-5-yl(5-chloro-8-hydroxyquinolin-7-yl)methyl)butyramide

参考文献

1. Soma Samanta, et al. Cancer Res. 2021 Apr 1;81(7):1883-1895.

YUM70 (YUM-70)

生物&药学活性

物理化学性质&存储条件

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YUM70 (YUM-70)

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