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首页-小分子抑制剂&激动剂-Others-Other Targets-YU252
YU252

Chemical Structure : YU252

CAS No.: 501693-48-7

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YU252 (YU239252)

货号: PC-72595Not For Human Use, Lab Use Only.

YU252 (YU239252) is a small molecule SPAK inhibitor with IC50 of 8.23 uM in in vitro SPAK ELISA assay at 10 uM ATP.

规格 价格 库存 数量
5 mg ￥1480 In stock
10 mg ￥2280 In stock
25 mg ￥3880 In stock
50 mg ￥5980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

YU252 (YU239252) is a small molecule SPAK inhibitor with IC50 of 8.23 uM in in vitro SPAK ELISA assay at 10 uM ATP.
YU252 decreases ion co-transporter activity and inhibits migration in glioblastoma cells by reducing both NKCC1 and KCC phosphorylation, inhibits glioblastoma proliferation and tumor growth in mice.
YU252 can potentially be used to inhibit the WNK/SPAK-OSR1 network in GBM and limit tumorigenesis in vivo.

物理化学性质&存储条件

分子量 431.351
分子式 C20H13F4N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(4-(4-aminofuro[2,3-d]pyrimidin-5-yl)phenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea

参考文献

1. Paula Schiapparelli, et al. Cell Rep. 2021 Jul 20;36(3):109416.

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