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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Proteasome-YU-101
YU-101

Chemical Structure : YU-101

CAS No.: 254888-42-1

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YU-101 (YU101, YU 101)

货号: PC-60971Not For Human Use, Lab Use Only.

YU-101 is a potent, specific proteasome β5 subunit inhibitor with IC50 of 0.26 uM, 7.3 and 17.3-fold selectivity over β2i and β1i subunit, respecitvely.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    YU-101 is a potent, specific proteasome β5 subunit inhibitor with IC50 of 0.26 uM, 7.3 and 17.3-fold selectivity over β2i and β1i subunit, respecitvely.

    物理化学性质&存储条件

    分子量 634.818
    分子式 C36H50N4O6
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-2-((S)-2-acetamido-4-phenylbutanamido)-4-methyl-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)pentanamide

    参考文献

    1. Screen M, et al. J Biol Chem. 2010 Dec 17;285(51):40125-34.

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