YTHDF2 Inhibitor CK-75 | YTHDF2 inhibitor | Probechem Biochemicals

Chemical Structure : YTHDF2 Inhibitor CK-75

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YTHDF2 Inhibitor CK-75 (CK75)

货号: PC-24105Not For Human Use, Lab Use Only.

YTHDF2 Inhibitor CK-75 is a specific small molecule inhibitor of YTHDF2, potentially binds to a small hydrophobic pocket on the YTH domain (KD=26.2 uM), potently inhibits the protein-RNA interaction of YTHDF2.

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生物&药学活性

YTHDF2 inhibitor CK-75 is a specific small molecule inhibitor of YTHDF2, potentially binds to a small hydrophobic pocket on the YTH domain (KD=26.2 uM), potently inhibits the protein-RNA interaction of YTHDF2.
CK-75 is inactive against the YTH domains of YTHDF1, YTHDF3, YTHDC1, and YTHDC2.
CK-75 induced cell cycle changes in K562 with increased arrest at the G0/G1 phase, induced apoptosis and inhibited colony formation, and showed moderate inhibitory activity against cell proliferation.

物理化学性质&存储条件

分子量	358.35
分子式	C21H14N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(2-hydroxy-1-naphthoyl)-1H-pyrazol-1-yl)benzoic acid

参考文献

1. Qiu X, et al. JACS Au. 2025 Feb 10;5(2):618-630.

YTHDF2 Inhibitor CK-75 (CK75)

生物&药学活性

物理化学性质&存储条件

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YTHDF2 Inhibitor CK-75 (CK75)

生物&药学活性

物理化学性质&存储条件

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