YTHDC1 inhibitor 40

Chemical Structure : YTHDC1 inhibitor 40

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货号: PC-22428Not For Human Use, Lab Use Only.

YTHDC1 inhibitor 40 is a potent, selective m6A reader YTHDC1 inhibitor with ITC Kd of 49 nM, HTRF IC50 of 0.35 uM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

YTHDC1 inhibitor 40 is a potent, selective m6A reader YTHDC1 inhibitor with ITC Kd of 49 nM, HTRF IC50 of 0.35 uM.
YTHDC1 inhibitor 40 exhibits antiproliferative activity against THP-1 (GI50 = 3.2 μM), MOLM-13 (5.6 μM) and NOMO-1 (8.2 μM), respectively.
YTHDC1 inhibitor 40 displays IC50 values of 89, 60, and 83 μM against YTHDF1, YTHDF2, and YTHDF3, respectively, indicating a 200-fold selectivity.
YTHDC1 inhibitor 40 does not display significant inhibition of a panel of 58 protein kinases.
YTHDC1 inhibitor 40 (2.5-10 uM) induces apoptosis in THP-1 cell line after 24 h treatment.
YTHDC1 inhibitor 40 is a tool compound for studying the role of YTHDC1 in AML.

物理化学性质&存储条件

分子量	308.17
分子式	C13H11Cl2N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-chloro-3-(3-chlorobenzyl)-N-methyl-2H-pyrazolo[4,3-d]pyrimidin-7-amine

参考文献

1. František Zálešák, et al. J Med Chem. 2024 May 24. doi: 10.1021/acs.jmedchem.4c00599.