YSN-1-167

Chemical Structure : YSN-1-167

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货号: PC-27830Not For Human Use, Lab Use Only.

YSN-1-167 is a small molecule inhibitor of Enterovirus 71 (EV71) infection with IC50 of 11.66 uM (viral RNA detection), inhibits viral replication by suppressing 3D polymerase (3Dpol) activity of EV71.

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生物&药学活性

YSN-1-167 is a small molecule inhibitor of Enterovirus 71 (EV71) infection with IC50 of 11.66 uM (viral RNA detection), inhibits viral replication by suppressing 3D polymerase (3Dpol) activity of EV71.
YSN-1-167 shows dose-dependent suppression of VP1 protein and viral RNA in Vero cells, with an IC50 of 9.64 μM.
YSN-1-167 exerts an antiviral effect by targeting the replication stage of the EV71 life cycle, but not the attachment and entry stages.
YSN-1-167 exerts anti-EV71 activity by inhibiting EV71 3D polymerase activity, potentially through interacting with the 3D protein.
YSN-1-167 significantly suppresses the inflammatory response induced by LPS treatment and EV71 infection.
YSN-1-167 (14 mg/kg) exerts anti-EV71 activity in mice, alleviates virus-induced muscle damage.

物理化学性质&存储条件

分子量	549.44
分子式	C23H22F4O4SSe
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(trifluoroseleninyl)propyl (Z)-2-(5-fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H-inden-3-yl)acetate

参考文献

1. Qi Y, et al. Antimicrob Agents Chemother. 2026 Jul;70(7):e0186425.

YSN-1-167

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物理化学性质&存储条件

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YSN-1-167

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