YSL-109 | HDAC6 inhibitor | Probechem Biochemicals

Chemical Structure : YSL-109

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YSL-109 (YSL109)

货号: PC-49678Not For Human Use, Lab Use Only.

YSL-109 (YSL109) is a potent, highly selective small molecule inhibitor of HDAC6 with IC50 of 0.537 nM, >4000-fold selectivity over HDAC1 and HDAC8.

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生物&药学活性

YSL-109 (YSL109) is a potent, highly selective small molecule inhibitor of HDAC6 with IC50 of 0.537 nM, >4000-fold selectivity over HDAC1 and HDAC8.
YSL-109 showed potent activity against hepatocellular carcinoma (HepG2 cell line, IC50=3.39 µM), breast cancer (MCF-7 cell line, IC50=3.41 µM; HCC1954 cell line, IC50=3.41 µM) and neuroblastoma (SH-SY5Y cell line, IC50=6.42 µM).
YSL-109 showed an antiproliferative activity TNBC cell line (MDA-MB231) with IC50 of 50 uM, lesser toxic on fibroblast.

物理化学性质&存储条件

分子量	390.48
分子式	C24H26N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-butyl-N-(1-(hydroxyamino)-3-(naphthalen-1-yl)-1-oxopropan-2-yl) benzamide

参考文献

1. Sixto-López Y, et al. Sci Rep. 2020 Jun 26;10(1):10462.

2. Sixto-López Y, et al. Naunyn Schmiedebergs Arch Pharmacol. 2023 Jan 25. doi: 10.1007/s00210-023-02396-7.

YSL-109 (YSL109)

生物&药学活性

物理化学性质&存储条件

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YSL-109 (YSL109)

生物&药学活性

物理化学性质&存储条件

参考文献

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