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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-YS3074
YS3074

Chemical Structure : YS3074

CAS No.:

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YS3074 (YS-3074)

货号: PC-27883Not For Human Use, Lab Use Only.

YS3074 is a potent and selective ENPP1 inhibitor with IC50 of 4.23 nM, shows weak to negligible ENPP2 and ENPP23 inhibition.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    YS3074 is a potent and selective ENPP1 inhibitor with IC50 of 4.23 nM, shows weak to negligible ENPP2 and ENPP23 inhibition.
    YS3074 enhanced cGAMP-induced expression of STING pathway genes (IFNB1, CXCL10, IL6) in a concentration-dependent manner without cytotoxicity.
    YS3074( 40 mg/kg) in combination with an anti-PD-1 antibody, achieved superior tumor growth inhibition, significantly prolonged survival in CT-26 colorectal cancer model.

    物理化学性质&存储条件

    分子量 545.46
    分子式 C25H23F3N5O4P
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    ((1-(2-(8-(2,6-difluorophenyl)imidazo[1,2-a]pyrazine-6-carboxamido)-4-fluorophenyl)piperidin-4-yl)methyl)phosphonic acid

    参考文献

    1. He Z, et al. Eur J Med Chem. 2026 Aug 25;319:119274.

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