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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-YS2219
YS2219

Chemical Structure : YS2219

CAS No.: 3058200-09-9

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YS2219 (Compound 7)

货号: PC-27884Not For Human Use, Lab Use Only.

YS2219 is a highly potent and selective ENPP1 inhibitor with IC50 of 5.70 or 9.68 nM, shows weak inhibition against ENPP2 and ENPP3 (IC50>2500 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

YS2219 is a highly potent and selective ENPP1 inhibitor with IC50 of 5.70 or 9.68 nM, shows weak inhibition against ENPP2 and ENPP3 (IC50>2500 nM).
YS2219 enhances the mRNA expression of cGAMP-induced STING pathway downstream target genes, such as IFNB1, CXCL10, and IL6.
YS2219 demonstartes enhancing the antitumor efficacy of the anti-PD-1 antibody in vivo.

物理化学性质&存储条件

分子量 557.58
分子式 C25H25F2N7O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(5-fluoro-2-(4-(sulfamoylamino)piperidin-1-yl)phenyl)-8-(2-fluoro-6-methoxyphenyl)imidazo[1,2-a]pyrazine-6-carboxamide

参考文献

1. Shiping Zhan, et al. Discovery of Imidazo[1,2- a]pyrazine Derivatives as Potent ENPP1 Inhibitors. J Med Chem. 2024 Oct 24;67(20):18317-18333.

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