YS-01

Chemical Structure : YS-01

加入收藏

货号: PC-27734Not For Human Use, Lab Use Only.

YS-01 is a potent, specific small molecule inhibitor of Cl-/HCO3- exchanger Pendrin (SLC26A4), potently inhibits pendrin-mediated Cl-/SCN-, Cl-/I-, Cl-/HCO3-, and Cl-/OH- exchange activity in a dose-dependent manner.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

YS-01 is a potent, specific small molecule inhibitor of Cl-/HCO3- exchanger Pendrin (SLC26A4), potently inhibits pendrin-mediated Cl-/SCN-, Cl-/I-, Cl-/HCO3-, and Cl-/OH- exchange activity in a dose-dependent manner.
YS-01 showsno cytotoxicity up to 30 μM in NIH3T3 and CHO-K1 cells and more potently inhibits pendrin activity than PDSinh-A01 and PDSinh-C01.
YS-01 inhibits both human and mouse pendrin-mediated Cl−/I− exchange with nearly identical potency.
YS-01 weakly inhibits Cl−/HCO3− exchange activities of SCL26A3 and SLC26A6 with IC50 greater than 100 μM and does not affect SCL26A7 and SLC26A9.
YS-01 significantly attenuated OVA-induced airway hyperresponsiveness and reduced the numbers of eosinophils and neutrophils in the bronchoalveolar lavage fluid of OVA-sensitized mice.

物理化学性质&存储条件

分子量	311.40
分子式	C18H17NO2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(tert-butyl)phenyl)-4-(thiophen-2-ylmethylene)oxazol-5(4H)-one

参考文献

1. Lee EH, et al. Theranostics. 2020 Aug 7;10(22):9913-9922.

2. Park J, et al. J Allergy Clin Immunol. 2019 Nov;144(5):1425-1428.e12.

YS-01

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

YS-01

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.