YQ-0629 | HIF-2α inhibitor | Probechem Biochemicals

Chemical Structure : YQ-0629

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YQ-0629 (YQ0629)

货号: PC-72532Not For Human Use, Lab Use Only.

YQ-0629 is a specific HIF-2α inhibitor, binds to HIF-2α PAS-B domain with Kd of 57.5 uM.

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生物&药学活性

YQ-0629 is a specific HIF-2α inhibitor, binds to HIF-2α PAS-B domain with Kd of 57.5 uM.
YQ-0629 could inhibit the expression of HIF-2α with or without the presence of PTX (3 nM) in MCF7 MS culture, does not bind to HIF-1α or affect the expression of HIF-1α.
YQ-0629 suppresses self-renewal capacity and synergizes with PTX to reverse the chemoresistance of MCF7 MS.
YQ-0629 inhibits growth of BCSCs derived from breast cancer patients and synergistically increases anti-BCSCs activity of PTX in vivo.

物理化学性质&存储条件

分子量	359.429
分子式	C22H21N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((benzyl(furan-2-ylmethyl)amino)methyl)-8-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

参考文献

1. Yan Y, et al. Cell Death Differ. 2022 Mar 17. doi: 10.1038/s41418-022-00963-8.

YQ-0629 (YQ0629)

生物&药学活性

物理化学性质&存储条件

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YQ-0629 (YQ0629)

生物&药学活性

物理化学性质&存储条件

参考文献

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