YPD-29B | PD-L1 inhibitor | Probechem Biochemicals

Chemical Structure : YPD-29B

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YPD-29B (IMMH-010 active metabolite)

货号: PC-20282Not For Human Use, Lab Use Only.

YPD-29B is a potent, specific programmed cell death ligand 1 (PD-L1) inhibitor, effectively blocks the binding of PD-1 and PD-L1 with IC50 of 0.08 pM in HTRF protein-protein interaction assays.

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100 mg		Get quote

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生物&药学活性

YPD-29B is a potent, specific programmed cell death ligand 1 (PD-L1) inhibitor, effectively blocks the binding of PD-1 and PD-L1 with IC50 of 0.08 pM in HTRF protein-protein interaction assays.
YPD-29B is the active metabolite of YPD-30 (Cat# PC-20281).
YPD-29B did not inhibit any other immune checkpoints, including hCD28/B7-1, hCD28/B7-2, hCTLA4/B7-1, and hCTLA4/B7-2 and LAG3/MHCII.
YPD-29B also suppressed the interaction of hPD-L1/hB7-1 with an IC50 of 0.3 nM.
YPD-29B binds to hPD-L1 with SPR KD of 0.02 nM, but not hPD-1. activates T lymphocytes and overcomes immunity tolerance by disrupting the hPD-1/PD-L1 interaction.
YPD-29B induces internalization and degradation of PD-L1.

物理化学性质&存储条件

分子量	597.89
分子式	C29H26BrClN2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-((2-bromo-[1,1'-biphenyl]-3-yl)methoxy)-5-chloro-2-(pyridin-3-ylmethoxy)benzyl)-L-serine

参考文献

1. Fangfang Lai, et al. Acta Pharm Sin B. 2022 Jun;12(6):2845-2858.

2. Wang Y, et al. Pharmaceutics. 2021 Apr 21;13(5):598.

3. Patent: CN109153670.

YPD-29B (IMMH-010 active metabolite)

生物&药学活性

物理化学性质&存储条件

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YPD-29B (IMMH-010 active metabolite)

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物理化学性质&存储条件

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