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首页-小分子抑制剂&激动剂-GPCR-Orexin Receptor-YNT-185
YNT-185

Chemical Structure : YNT-185

CAS No.: 1804978-81-1

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YNT-185 (YNT185)

货号: PC-73244Not For Human Use, Lab Use Only.

YNT-185 is a potent, selective orexin type-2 receptor (OX2R) agonist with EC50 of 28 nM, 100-fold selectivity over OX1R.

规格 价格 库存 数量
5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3280 In stock
50 mg ￥5280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

YNT-185 is a potent, selective orexin type-2 receptor (OX2R) agonist with EC50 of 28 nM, 100-fold selectivity over OX1R.
YNT-185 epolarized OX2-expressing histaminergic neurons in mouse brain slices.
YNT-185 suppressed cataplexy-like episodes in orexin knockout and orexin neuron-ablated mice, but not in orexin receptor-deficient mice.
Peripherally administered YNT-185 also promotes wakefulness without affecting body temperature in wild-type mice.

物理化学性质&存储条件

分子量 615.74
分子式 C33H37N5O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3'-(N-(3-((2-(2-(dimethylamino)benzamido)ethyl)amino)phenyl)sulfamoyl)-4'-methoxy-N,N-dimethyl-[1,1'-biphenyl]-3-carboxamide

参考文献

1. Irukayama-Tomobe Y, et al. Proc Natl Acad Sci U S A. 2017 May 30;114(22):5731-5736.

2. Toyama S, et al. Anesthesiology. 2018 May;128(5):992-1003.

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