YM976 | PDE4 inhibitor | Probechem Biochemicals

Chemical Structure : YM976

CAS No.: 191219-80-4

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YM976 (YM-976)

货号: PC-22040Not For Human Use, Lab Use Only.

YM976 is a potent, selective phosphodiesterase type 4 (PDE4) inhibitor with IC50 of 2.2 nM against PDE4 purified from human peripheral leukocytes.

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25 MG	￥1380	In stock
50 MG	￥2180	In stock
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生物&药学活性

YM976 is a potent, selective phosphodiesterase type 4 (PDE4) inhibitor with IC50 of 2.2 nM against PDE4 purified from human peripheral leukocytes.
YM976 has no effects on the other PDE isozymes, PDE1, -2, -3, and -5.
YM976 potentiates prostaglandin E(2)-induced cAMP accumulation in a human mononuclear cell line, U937, and YM976 inhibits TNF-alpha production from human peripheral blood mononuclear cells stimulated by lipopolysaccharide.
YM976 inhibits the cell infiltration into the pleural cavity with oral ED(30) values of 9.1 mg/kg in rat carrageenan-induced pleurisy models.
YM976 dose dependently reduces carrageenan-induced leukocyte infiltration at the doses of 1, 3, and 10 mg/kg, p.o.

物理化学性质&存储条件

分子量	313.79
分子式	C17H16ClN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3-Chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one

参考文献

1. Aoki M, et al. J Pharmacol Exp Ther. 2000 Oct;295(1):255-60.

2. Aoki M, et al. J Pharmacol Exp Ther. 2000 Dec;295(3):1149-55.

YM976 (YM-976)

生物&药学活性

物理化学性质&存储条件

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YM976 (YM-976)

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物理化学性质&存储条件

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