YM 758 |CAS:312752-86-6 Probechem Biochemicals

Chemical Structure : YM 758

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YM 758 (YM758;YM-758)

货号: PC-60990Not For Human Use, Lab Use Only.

A novel potent "funny" If current channel (If channel) inhibitor that inhibits rOct1- and hOCT1-mediated [3H]MPP uptake with IC50 of 23.8 and 40.5 uM, respectively.

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生物&药学活性

A novel potent "funny" If current channel (If channel) inhibitor that inhibits rOct1- and hOCT1-mediated [3H]MPP uptake with IC50 of 23.8 and 40.5 uM, respectively; inhibits OATP1B1-mediated [3H]E217βG uptake in HEK293 cells with IC50 of 13.0 uM and has no inhibitory effect on OATP1B3-mediated [3H]E217βG uptake; selectively lowers the heart rate and decreases oxygen consumption by heart muscle.

物理化学性质&存储条件

分子量	469.557
分子式	C26H32FN3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(-)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide monophosphate

参考文献

1. Umehara K, et al. Drug Metab Dispos. 2008 Jun;36(6):1030-8.

2. Umehara KI, et al. Xenobiotica. 2008 May;38(5):527-39.

3. Umehara KI, et al. Eur J Drug Metab Pharmacokinet. 2008 Oct-Dec;33(4):211-23.

4. Nakada N. Drugs R D. 2016 Jun;16(2):205-16.

YM 758 (YM758;YM-758)

生物&药学活性

物理化学性质&存储条件

参考文献

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YM 758 (YM758;YM-758)

生物&药学活性

物理化学性质&存储条件

参考文献

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