YM543 | SGLT2 inhibitor | Probechem Biochemicals

Chemical Structure : YM543

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YM543 (YM-543, YM 543)

货号: PC-60987Not For Human Use, Lab Use Only.

YM543 is a potent, selective and orally active SGLT2 inhibitor with IC50 of 8.9 nM, 280-fold selectivity over SGLT1.

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生物&药学活性

YM543 is a potent, selective and orally active SGLT2 inhibitor with IC50 of 8.9 nM, 280-fold selectivity over SGLT1.
YM543 dose-dependently and significantly reduces blood glucose levels and improves glucose tolerance with a concomitant increase in urinary glucose excretion.
YM543 also significantly reduces hyperglycemia in type 2 diabetic mice.

物理化学性质&存储条件

分子量	500.611
分子式	C28H38NO7+
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3R,4R,5S,6R)-2-(5-(azulen-2-ylmethyl)-2-hydroxyphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, 2-hydroxy-N,N,N-trimethylethan-1-aminium salt

参考文献

1. Yokono M, et al. Endocr Res. 2013 Feb 1.

2. Ikegai K, et al. Bioorg Med Chem. 2013 Jul 1;21(13):3934-48.

3. Nakada N. Pharm Res. 2017 Apr;34(4):874-886.

YM543 (YM-543, YM 543)

生物&药学活性

物理化学性质&存储条件

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YM543 (YM-543, YM 543)

生物&药学活性

物理化学性质&存储条件

参考文献

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