YM-58483 | CRAC channel inhibitor | Probechem Biochemicals

Chemical Structure : YM-58483

CAS No.: 223499-30-7

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YM-58483 (YM58483, BPT2)

货号: PC-42271Not For Human Use, Lab Use Only.

YM-58483 is a potent store-operated Ca2+ entry blocker and CRAC channel inhibitor with IC50 of 100 nM.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

YM-58483 is a potent store-operated Ca2+ entry blocker and CRAC channel inhibitor with IC50 of 100 nM.
YM-58483 inhibits Ca(2+) influx through SOC channels without affecting the TCR signal transduction cascade in Jurkat cells, inhibits thapsigargin-induced sustained Ca(2+) influx (IC50=100 nM), and 30-fold less potent against Cav channels.
YM-58483 potently inhibits IL-2 production and NF-AT-driven promoter activity in Jurkat cells.
YM-58483 also inhibits IL-4 and IL-5 production Th2 T cells, prevents antigen-induced inflammatory responses in animal models; orally active.

物理化学性质&存储条件

分子量	421.3203
分子式	C15H9F6N5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 32 mg/mL
Chemical Name/SMILES	1,2,3-Thiadiazole-5-carboxamide, N-[4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-

参考文献

1. Ishikawa J, et al. J Immunol. 2003 May 1;170(9):4441-9.

2. Yoshino T, et al. Eur J Pharmacol. 2007 Apr 10;560(2-3):225-33.

3. Takezawa R, et al. Mol Pharmacol. 2006 Apr;69(4):1413-20.

4. Zitt C, et al. J Biol Chem. 2004 Mar 26;279(13):12427-37.

YM-58483 (YM58483, BPT2)

生物&药学活性

物理化学性质&存储条件

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YM-58483 (YM58483, BPT2)

生物&药学活性

物理化学性质&存储条件

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