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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-YM-344484
YM-344484

Chemical Structure : YM-344484

CAS No.: 671205-14-4

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YM-344484 (YM344484)

货号: PC-20732Not For Human Use, Lab Use Only.

YM-344484 (YM344484) is a potent, selective dual antagonist of chemokine CCR3 receptor and histamine H1 receptor, potently inhibits both the CCL11-induced Ca2+ influx in human CCR3-expressing cells (Kb=1.8 nM) and histamine-induced Ca2+ influx in histamine H1 receptor-expressing PC3 cells (Kb=47 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

YM-344484 (YM344484) is a potent, selective dual antagonist of chemokine CCR3 receptor and histamine H1 receptor, potently inhibits both the CCL11-induced Ca2+ influx in human CCR3-expressing cells (Kb=1.8 nM) and histamine-induced Ca2+ influx in histamine H1 receptor-expressing PC3 cells (Kb=47 nM).

物理化学性质&存储条件

分子量 487.58
分子式 C28H30FN5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(N[C@H]1CN(CC2=CC=C3C=C(F)C=CC3=C2)CC1)/C=C4CCN(C(C5=NN=C(C)C=C5)=O)CC\4

参考文献

1. Suzuki K, et al. Eur J Pharmacol. 2007 Jun 1;563(1-3):224-32.

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