YM-344484 | Dual CCR3/H1 antagonist | Probechem Biochemicals

Chemical Structure : YM-344484

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YM-344484 (YM344484)

货号: PC-20732Not For Human Use, Lab Use Only.

YM-344484 (YM344484) is a potent, selective dual antagonist of chemokine CCR3 receptor and histamine H1 receptor, potently inhibits both the CCL11-induced Ca2+ influx in human CCR3-expressing cells (Kb=1.8 nM) and histamine-induced Ca2+ influx in histamine H1 receptor-expressing PC3 cells (Kb=47 nM).

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生物&药学活性

YM-344484 (YM344484) is a potent, selective dual antagonist of chemokine CCR3 receptor and histamine H1 receptor, potently inhibits both the CCL11-induced Ca2+ influx in human CCR3-expressing cells (Kb=1.8 nM) and histamine-induced Ca2+ influx in histamine H1 receptor-expressing PC3 cells (Kb=47 nM).

物理化学性质&存储条件

分子量	487.58
分子式	C28H30FN5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(1-((6-fluoronaphthalen-2-yl)methyl)pyrrolidin-3-yl)-2-(1-(6-methylpyridazine-3-carbonyl)piperidin-4-ylidene)acetamide

参考文献

1. Suzuki K, et al. Eur J Pharmacol. 2007 Jun 1;563(1-3):224-32.

YM-344484 (YM344484)

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物理化学性质&存储条件

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YM-344484 (YM344484)

生物&药学活性

物理化学性质&存储条件

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