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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-PIKfyve-YM-201636
YM-201636

Chemical Structure : YM-201636

CAS No.: 371942-69-7

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YM-201636 (YM 201636, YM201636)

货号: PC-43409Not For Human Use, Lab Use Only.

YM-201636 is a potent, selective PIKfyve inhibitor with IC50 of 33 nM, does not inhibit type Iiγ/Iα PtdInsP kinases even at 10 uM (p110α IC50=3.3 uM).

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5 mg ￥880 In stock
10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

YM-201636 is a potent, selective PIKfyve inhibitor with IC50 of 33 nM, does not inhibit type Iiγ/Iα PtdInsP kinases even at 10 uM (p110α IC50=3.3 uM).
YM-201636 shows insensitivity against yeast orthologue of PIKfyve, Fab1; significantly decreases the production of PtdIns(3,5)P2 by 80% in serum-starved NIH3T3 cells with no effect on serum-stimulated PKB Ser 473 phosphorylation at 0.8 uM.
YM-201636 inhibits basal and insulin-activated 2-deoxyglucose uptake withIC50 of 54 nM.
YM-201636 significantly reduces retroviruses budding from cells; blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells.

物理化学性质&存储条件

分子量 467.4793
分子式 C25H21N7O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 47 mg/mL

Chemical Name/SMILES

3-Pyridinecarboxamide, 6-amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-

参考文献

1. Jefferies HB, et al. EMBO Rep. 2008 Feb;9(2):164-70.

2. Osborne SL, et al. J Biol Chem. 2008 Feb 1;283(5):2804-13.

3. Ikonomov OC, et al. Biochem Biophys Res Commun. 2009 May 8;382(3):566-70.

4. Kerr MC, et al. EMBO J. 2010 Apr 21;29(8):1331-47.

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