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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-YM-1
YM-1

Chemical Structure : YM-1

CAS No.: 409086-68-6

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YM-1 (YM1, Hsp70 inhibitor)

货号: PC-62198Not For Human Use, Lab Use Only.

YM-1 is a close derivative of MTK-077 that allosterically promotes Hsp70 binding to unfolded substrates, specificly binds to Hsp70 with Kd of 4.9 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

YM-1 is a close derivative of MTK-077 that allosterically promotes Hsp70 binding to unfolded substrates, specificly binds to Hsp70 with Kd of 4.9 uM.
YM-1 enhances client protein ubiquitination and polyQ AR degradation.
YM-1 alleviates toxicity in a Drosophila model of spinobulbar muscular atrophy (SBMA).
YM-1 also disrupts the Hsp70-Bag3 interaction with IC50 of 5 uM.

物理化学性质&存储条件

分子量 417.97
分子式 C20H20ClN3OS2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((Z)-((E)-3-Ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)-1-methylpyridin-1-ium chloride

参考文献

1. Wang AM, et al. Nat Chem Biol. 2013 Feb;9(2):112-8.

2. Morishima Y, et al. Biochemistry. 2011 Aug 23;50(33):7146-56.

3. Colvin TA, et al. Cancer Res. 2014 Sep 1;74(17):4731-40.

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