YLIU-5-162-1

Chemical Structure : YLIU-5-162-1

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货号: PC-20901Not For Human Use, Lab Use Only.

YLIU-4-105-1 is a novel type II JAK2 inhibitor, binds to JAK2 kinase domain (JH1), show potential for overcoming acquired resistance to ruxolitinib.

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生物&药学活性

YLIU-4-105-1 is a novel type II JAK2 inhibitor, binds to JAK2 kinase domain (JH1), show potential for overcoming acquired resistance to ruxolitinib.
YLIU-4-105-1 shows pure JAK2 selectivity, inhibits pSTAT1 (Y701) and in some cases pERK1/2 (T202/Y204) to varying extents, but does not inhibit pAKT (T308).
YLIU-4-105-1 is more potent against JAK2 V617F-dependent SET2 cells.
YLIU-4-105-1 (50 mg/kg or 75 mg/kg, IP daily) shows abdominal ascites, intraabdominal drug precipitate, and dilated loops of bowel on rhEPO-induced polycythemia mouse model.

物理化学性质&存储条件

分子量	605.67
分子式	C32H34F3N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2-(cyclopropanecarboxamido)imidazo[1,2-b]pyridazin-6-yl)-N-(3-((4-ethylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)-4-methylbenzamide

参考文献

1. Matthew L Arwood, et al. Cell Chem Biol. 2023 Jun 15;30(6):618-631.e12.

YLIU-5-162-1

生物&药学活性

物理化学性质&存储条件

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YLIU-5-162-1

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物理化学性质&存储条件

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