YL5084 | JNK2/3 inhibitor | Probechem Biochemicals

Chemical Structure : YL5084

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YL5084 (YL 5084)

货号: PC-49846Not For Human Use, Lab Use Only.

YL5084 (YL 5084) is a potent, selective and covalent JNK2/3 inhibitor with IC50 of 70 nM (JNK2), displays selectivity (>30-fold) for JNK2 over JNK1.

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生物&药学活性

YL5084 (YL 5084) is a potent, selective and covalent JNK2/3 inhibitor with IC50 of 70 nM (JNK2), displays selectivity (>30-fold) for JNK2 over JNK1.
YL5084 forms a covalent bond with Cys116 of JNK2, exhibits a 20-fold higher Kinact/KI compared to that of JNK1, and engages JNK2 in cells.
YL5084 exhibited JNK2-independent antiproliferative effects in multiple myeloma cells.

物理化学性质&存储条件

分子量	600.73
分子式	C35H36N8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-4-(dimethylamino)-N-(4-((3S,4S)-3-methyl-4-((4-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-yl)amino)pyrrolidine-1-carbonyl)phenyl)but-2-enamide

参考文献

1. Wenchao Lu, et al. J Med Chem. 2023 Mar 9;66(5):3356-3371.

YL5084 (YL 5084)

生物&药学活性

物理化学性质&存储条件

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YL5084 (YL 5084)

生物&药学活性

物理化学性质&存储条件

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