YL3147 | Ferroptosis inhibitor | Probechem Biochemicals

Chemical Structure : YL3147

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YL3147 (YL-3147)

货号: PC-28622Not For Human Use, Lab Use Only.

YL3147 is a radical-trapping antioxidant and potent ferroptosis inhibitor with EC50 of 0.8 nM (Erastin-induced ferroptosis in ES-2 cells), directly halting the propagation of lipid peroxidation and thereby blocking ferroptosis, protecting doxorubicin-induced cardiomyopathy in both acute and chronic murine models.

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生物&药学活性

YL3147 is a radical-trapping antioxidant and potent ferroptosis inhibitor with EC50 of 0.8 nM (Erastin-induced ferroptosis in ES-2 cells), directly halting the propagation of lipid peroxidation and thereby blocking ferroptosis, protecting doxorubicin-induced cardiomyopathy in both acute and chronic murine models.

物理化学性质&存储条件

分子量	402.51
分子式	C25H27FN4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5H-Dibenzo[b,e][1,4]diazepine, 1-(3,4-dimethyl-1-piperazinyl)-3-(3-fluorophenyl)-10,11-dihydro-

参考文献

1. Jing You, et al. J Med Chem. 2026 Feb 12;69(3):2996-3017.

YL3147 (YL-3147)

生物&药学活性

物理化学性质&存储条件

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YL3147 (YL-3147)

生物&药学活性

物理化学性质&存储条件

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