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首页-小分子抑制剂&激动剂-Others-Other Targets-YL0441
YL0441

Chemical Structure : YL0441

CAS No.:

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YL0441 (YL-0441)

货号: PC-25798Not For Human Use, Lab Use Only.

YL0441 is a highly effective inhibitor of AP1 transcription factor ΔFOSB with IC50 of 13.7 uM and 12.3 uM, disrupts ΔFOSB/JUND and ΔFOSB/ΔFOSB binding to DNA, inhibits AP1-transcription factor-mediated expression of the luciferase reporter gene with IC50 of 0.1 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

YL0441 is a highly effective inhibitor of AP1 transcription factor ΔFOSB with IC50 of 13.7 uM and 12.3 uM, disrupts ΔFOSB/JUND and ΔFOSB/ΔFOSB binding to DNA, inhibits AP1-transcription factor-mediated expression of the luciferase reporter gene with IC50 of 0.1 uM.
YL0441 efficiently disrupts ΔFOSB binding to genomic DNA in brain in vivo, interferes with ΔFOSB binding to DNA and/or promotes its release from chromatin in dorsal hippocampus of APP mice.

物理化学性质&存储条件

分子量 385.39
分子式 C19H15NO6S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-5-(3-(furan-2-yl)acrylamido)-2-phenoxybenzenesulfonic acid

参考文献

1. McNeme S, et al. bioRxiv [Preprint]. 2025 Oct 23:2025.10.21.683721.

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