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首页-小分子抑制剂&激动剂-Apoptosis-Ferroptosis-YL-939
YL-939

Chemical Structure : YL-939

CAS No.: 3023925-68-7

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YL-939 (YL939)

货号: PC-49555Not For Human Use, Lab Use Only.

YL-939 is a novel non-classical and specific ferroptosis inhibitor, targets and binds directly to the prohibitin 2 (PHB2) protein with Kd of 3.43 uM in SPR assays.

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5 mg ￥2480 In stock
10 mg ￥3980 In stock
25 mg ￥6580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

YL-939 is a novel non-classical and specific ferroptosis inhibitor, targets and binds directly to the prohibitin 2 (PHB2) protein with Kd of 3.43 uM in SPR assays.
YL-939 is not an inhibitor of apoptosis, necroptosis, pyroptosis, and cuprotosis. did not show impact on the currently known signal pathways regulating ferroptosis.
YL-939 specifically protected cells from ferroptosis in erastin-induced ferroptosis models (HT1080 and ES-2) with EC50 of 0.14 and 0.09 uM, repectively.
YL-939 protected PHB2 from the degradation by pronase, but had no effect on the PHB2 isoform PHB1, as well as VDAC1 and VDAC2.
YL-939 treatment dose-dependently up-regulated ferritin protein and the mRNA expression of FTH1 and FTL, similar to the effect of PHB2 knockdown, also dose-dependently reduced the intracellular iron level elevated by erastin treatment, blocked autophagosomes/lysosomes, and hence inhibited ferritinophagy.
YL-939 (3 mg/kg) ameliorated liver damage in an acetaminophen (APAP)-induced acute liver injury model.

物理化学性质&存储条件

分子量 426.524
分子式 C25H26N6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

8-(3,6-dihydro-2H-pyran-4-yl)-2-phenyl-6-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-a]pyrazine

参考文献

1. Wei Yang, et al. Nat Commun. 2022 Dec 3;13(1):7473.

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