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首页-小分子抑制剂&激动剂-Others-Other Targets-YL-365
YL-365

Chemical Structure : YL-365

CAS No.:

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YL-365 (YL365)

货号: PC-21213Not For Human Use, Lab Use Only.

YL-365 (YL365) is a highly potent, selective and competitive antagonist of GPR34.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

YL-365 (YL365) is a highly potent, selective and competitive antagonist of GPR34.
YL-365 binds to a portion of the orthosteric binding pocket of GPR34 and the antagonist-binding-induced allostery in the receptor, implicating the inhibition mechanism.
YL-365 displays excellent activity in a neuropathic pain model without obvious toxicity.

物理化学性质&存储条件

分子量 583.08
分子式 C34H31ClN2O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(2-(4-(benzyloxy)phenyl)acetamido)-1-(3'-chloro-[1,1'-biphenyl]-4-carbonyl)piperidine-4-carboxylic acid

参考文献

1. Anjie Xia, et al. Proc Natl Acad Sci U S A. 2023 Sep 26;120(39):e2308435120.

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