YKL-1-116 | CDK7 inhibitor | Probechem Biochemicals

首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-YKL-1-116

Chemical Structure : YKL-1-116

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YKL-1-116 (CDK7 inhibitor)

货号: PC-60961Not For Human Use, Lab Use Only.

YKL-1-116 is a potent, selective and covalent inhibitor of CDK7 that does not inhibit other CDKs.

规格	价格	库存	数量
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

YKL-1-116 is a potent, selective and covalent inhibitor of CDK7 that does not inhibit other CDKs.
YKL-1-116 synergizes with 5-FU or nutlin-3 to kill HCT116 cells, produces dose-dependent increases in PARP cleavage.
YKL-1-116 is more potent than THZ1 towards both Cdk7WT and Cdk7as (analog-sensitive mutant).

物理化学性质&存储条件

分子量	606.731
分子式	C34H38N8O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-((3-(4-acrylamidobenzamido)phenyl)amino)-N-(2-(dimethylamino)-1-phenylethyl)-6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide

参考文献

1. Kalan S, et al. Cell Rep. 2017 Oct 10;21(2):467-481.

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YKL-1-116 (CDK7 inhibitor)

生物&药学活性

物理化学性质&存储条件

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YKL-1-116 (CDK7 inhibitor)

生物&药学活性

物理化学性质&存储条件

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