YKL-06-061 | SIK inhibitor | Probechem Biochemicals

Chemical Structure : YKL-06-061

CAS No.: 2172617-15-9

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YKL-06-061 (YKL06-061)

货号: PC-63122Not For Human Use, Lab Use Only.

YKL-06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 of 6.56/1.77/20.5 nM for SIK1/2/3, respectively.

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5 mg	￥880	In stock
10 mg	￥1380	In stock
25 mg	￥2180	In stock
50 mg	￥3480	In stock
100 mg		Get quote

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生物&药学活性

YKL-06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 of 6.56/1.77/20.5 nM for SIK1/2/3, respectively.
YKL-06-061 inhibits only one kinase FRK (IC50=1.1 nM), more strongly than SIKs, in a panel of 468 human kinases.
YKL-06-061 dose-dependently increases MITF mRNA expression in human melanoma cells.
YKL-06-061 induces significant pigmentation in Mc1r-deficient mice and normal human skin.

物理化学性质&存储条件

分子量	527.673
分子式	C30H37N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Pyrimido[4,5-d]pyrimidin-2(1H)-one,1-cyclobutyl-3-(2,6-dimethylphenyl)-3,4-dihydro-7-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-

参考文献

1. Mujahid N, et al. Cell Rep. 2017 Jun 13;19(11):2177-2184.

YKL-06-061 (YKL06-061)

生物&药学活性

物理化学性质&存储条件

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YKL-06-061 (YKL06-061)

生物&药学活性

物理化学性质&存储条件

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